Variations in Human Milk Metabolites After Gestational Diabetes: Associations with Infant Growth.

ABSTRACT:

Background/objectives

Gestational diabetes mellitus (GDM) is a condition characterized by hyperglycemia and is associated with increased risk of obesity and diabetes in exposed children. Differences in human milk composition between women with (GDM+) and without GDM (GDM-) suggest that GDM could impact milk production and composition, potentially influencing infant growth. However, this association remains poorly understood. The objective was to study the association between GDM and human milk composition and its influence on infant growth, focusing on metabolites and bioactive molecules involved in energy metabolism.

Methods

Using a cross-sectional design, 24 metabolites were measured by GC-MS in human milk obtained at 2 months postpartum from 20 GDM+ women and 29 GDM- wome

SUBMITTER: Fradet A 

PROVIDER: S-EPMC12073254 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature