Stereoselectivity of In Vivo Processes and Bioactivity of Farrerol Enantiomers.

ABSTRACT: Farrerol, a bioactive compound found in Folium Rhododendri daurici, demonstrates various biological and pharmacological effects. Nevertheless, the stereoselectivity of in vivo processes and bioactivity between its enantiomers have not been thoroughly investigated. This study aimed to explore the stereoselectivity and pharmacological activity variations in farrerol enantiomers, focusing on stereoselective pharmacokinetics, tissue distribution, in vitro metabolism using liver microsomes, in vivo intestinal absorption, molecular simulations of binding affinity with antiproliferative target, and cell viability assessed through the CCK-8 assay. The findings indicated that the pharmacokinetic characteristics of farrerol in rats' plasma, liver, and kidney tissues displayed enantioselectivity afte

SUBMITTER: Chen L 

PROVIDER: S-EPMC12073438 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature