Antioxidant and Anticancer Mechanisms of Unique Polyphenols in <i>Camellia ptilophylla</i>: Focus on Gallocatechin-3,5-di-O-gallate and 1,2,4,6-Tetra-O-galloyl-β-D-glucopyranose.

ABSTRACT: Camellia ptilophylla Chang (C. ptilophylla), a unique low-caffeine tea species, is valued for its bioactive properties, especially antioxidant and anticancer activities, due to its distinct phytochemical profile. However, its precise constituents and mechanisms remain poorly understood. This study employs an integrated approach combining chromatographic separation, bioinformatic analysis, and cellular assays to systematically investigate the antioxidant and anticancer properties of C. ptilophylla and elucidate its underlying molecular mechanisms. Quantitative analysis revealed that in addition to trans-catechins, the unique polyphenolic compounds, gallocatechin-3,5-di-O-gallate (GC-3,5-diGA) and 1,2,4,6-tetra-O-galloyl-β-D-glucopyranose (1,2,4,6-GA-glc), constit

SUBMITTER: Zhou L 

PROVIDER: S-EPMC12073820 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature