Differential Organ Ageing Is Associated With Age-Related Macular Degeneration.

ABSTRACT: Age-related macular degeneration (AMD) is a progressive disorder and the leading cause of central vision loss. Age is the most important risk factor, followed by genetics and smoking. However, ageing is a complex process, and biological age can deviate from chronological age between individuals and within different organ systems. Initially, we used machine learning to predict the biological age of the immune, cardiovascular, pulmonary, renal, musculoskeletal, metabolic and hepatic systems by analysing various physiological and physical markers in the UK Biobank cohort. Then, we investigated the association of each organ's biological age with incident AMD derived from electronic health record data as well as with different AMD genetic risk scores. We observed that most organ systems in part

SUBMITTER: Papadam A 

PROVIDER: S-EPMC12073918 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature