Measures of Adiposity and Risk of Rheumatoid Arthritis in Middle-Aged UK Women: A Prospective Cohort Study.

ABSTRACT: Objectives: To estimate the association between various indicators of obesity-related health risk and the incidence of rheumatoid arthritis (RA) in a large cohort of women. Methods: The UK Women's Cohort Study is a prospective cohort of 35,372 middle-aged women (aged 35-69 at recruitment) initiated in 1995-1998. Obesity was assessed using body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), categorised according to WHO and NICE guidelines, as well as clothing size. Incident RA cases were identified via Hospital Episode Statistics (HES) linkage up to March 2019. Cox regression models were used to estimate RA risk, adjusting for demographics, reproductive factors, and lifestyle factors. Non-linear associations were examined us

SUBMITTER: Dong Y 

PROVIDER: S-EPMC12074165 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature