Effects of Astraflavonoid A and Astraside C from the Aerial Part of <i>Astragalus membranaceus</i> on TNF-α-Induced Human Dermal Fibroblasts.

ABSTRACT: The present study investigates the anti-skin-aging properties and bioactive compounds of the aerial parts of Astragalus membranaceus, which are typically discarded as agricultural waste. Liquid chromatography-mass spectrometry analysis identified flavonoid glycosides as the major constituents of the aerial parts of A. membranaceus extract. Two principal flavonoids, astraflavonoid A (1) and astraside C (2), were isolated using repetitive chromatography. Compounds 1 and 2 demonstrated antioxidative properties, reducing reactive oxygen species and matrix metalloproteinase-1 levels in human dermal fibroblasts upon stimulation with TNF-α. Specifically, astraside C (2) inhibited the expression of pro-inflammatory cytokines interleukin-6 and

SUBMITTER: Son SR 

PROVIDER: S-EPMC12074202 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature