The neuroprotective role of CncC in a Drosophila model of Parkinson's disease.

ABSTRACT: Parkinson's disease (PD) is an incurable neurodegenerative disorder, yet significant advancements have been made in understanding its etiology. Among the risk factors, exposure to neurotoxins plays the greatest role. One of the most dangerous toxins is rotenone, a naturally derived compound that was historically used as an insecticide. This chemical affects mitochondrial function by blocking electron transfer, resulting in increased reactive oxygen species production and accumulation. Recently, the role of the Nrf2 pathway was explored as a possible protective mechanism to minimize the neurotoxic effects leading to Parkinson's disease. Here, we used Drosophila melanogaster as a model to examine the link between the expression or activity levels of CncC (an ortholog of Nrf2) or HO (an ortho

SUBMITTER: Abaquita TAL 

PROVIDER: S-EPMC12074349 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature