Development of a Suite of Gadolinium-Free OATP1-Targeted Paramagnetic Probes for Liver MRI.

ABSTRACT: Five amphiphilic, anionic Mn(II) complexes were synthesized as contrast agents targeted to organic anion transporting polypeptide transporters (OATP) for liver magnetic resonance imaging (MRI). The Mn(II) complexes are synthesized in three steps, each from the commercially available trans-1,2-diaminocyclohexane-N,N,N',N'-tetraacetic acid (CDTA) chelator, with T₁-relaxivity of complexes ranging between 2.3 and 3.0 mM^-1 s^-1 in phosphate buffered saline at an applied field strength of 3.0 T. Pharmacokinetics were assessed in female BALB/c mice by acquiring T₁-weighted images dynamically for 70 min after agent administration and determining contrast enhancement and washout in various organs. Uptake of

SUBMITTER: McRae SW 

PROVIDER: S-EPMC12074583 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature