New polymorphisms of Vkork1 gene related to anticoagulant resistance of rats and mice in Italy.

ABSTRACT:

Background

Anticoagulant rodenticides (ARs) are a very effective tool to control rodent pest populations. Nevertheless, AR resistance has been documented worldwide. ARs block the cycle of vitamin K, leading to the death of the animal by internal bleeding: mutations in Vkorc1 gene can cause resistance. The spreading of AR-resistant rodents could lead to an increase of their populations, the associated diffusion of zoonotic pathogens, and to the amplified exposure of non-target animals to ARs, thus it is important to study its diffusion widely. This study aimed to report firstly the presence of Vkorc1 mutations in synanthropic rodents from the Emilia-Romagna region, Italy, and evaluate their role in resistance by means of molecular docking analysis.

Results

A total of 67 anima

SUBMITTER: Reggiani A 

PROVIDER: S-EPMC12074628 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature