Examination of Inter-α Inhibitor Proteins in Permanent and Transient Focal Ischemia.

ABSTRACT:

Background

Ischemic stroke is among the most prevalent diseases, with high death and morbidity. Numerous preclinical studies have reported efficacious interventions in rodent stroke models. However, reperfusion therapies remain the only clinically efficacious intervention to date. Rigor and reproducibility are now recognized as critical to bridge the preclinical-clinical disconnect. Inter-α inhibitor proteins (IαIPs) are a family of structurally related glycoproteins with 2 major forms (inter-α inhibitor and pre-α inhibitor) in blood. Purified human plasma-derived IαIP has beneficial effects in sepsis and hypoxic-ischemic brain injury. More recently, IαIP improved focal ischemic stroke outcomes in mouse models. Here, we tested IαIP efficacy in both transient and permanent stroke mo

SUBMITTER: Imai T 

PROVIDER: S-EPMC12074731 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature