Proteome-Wide Mendelian Randomization Identifies Therapeutic Targets for Abdominal Aortic Aneurysm.

ABSTRACT:

Background

The proteome is a key source of therapeutic targets. We conducted a comprehensive Mendelian randomization analysis across the proteome to identify potential protein markers and therapeutic targets for abdominal aortic aneurysm (AAA).

Methods and results

Our study used plasma proteomics data from the UK Biobank, comprising 2923 proteins from 54 219 individuals, and from deCODE Genetics, which measured 4907 proteins across 35 559 individuals. Significant proteomic quantitative trait loci were used as instruments for Mendelian randomization. Genetic associations with AAA were sourced from the AAAgen consortium, a large-scale genome-wide association study meta-analysis involving 37 214 cases and 1 086 107 controls, and the FinnGen study, which included 3869 cases and

SUBMITTER: Zhang K 

PROVIDER: S-EPMC12074732 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature