Pathological Characterization of African Swine Fever Viruses With Genetic Deletions Detected in South Korea.

ABSTRACT: African swine fever virus (ASFV) genotype II has been circulating in South Korea, causing substantial economic losses to the Korean pig industry since 2019. Genetic epidemiological investigations using whole-genome sequencing have been conducted to track the genetic evolution of ASFV. Two ASFV strains were detected in domestic pig farms in South Korea, one with a large deletion in the MGF 360-6L gene and the other in the MGF 360-21R gene. Phylogenetic analysis indicated that all Korean isolates belonged to the Asian subgroup of ASFV genotype II and were further divided into distinct subclusters of Korean African swine fever (ASF) group I. To identify the pathological changes caused by the deletion of MGF 360-6L and MGF 360-21R genes, we evaluated their pathogenicity in experimentally infec

SUBMITTER: Hong SK 

PROVIDER: S-EPMC12074837 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature