Clonal dynamics and somatic evolution of haematopoiesis in mouse.

ABSTRACT: Haematopoietic stem cells maintain blood production throughout life¹. Although extensively characterized using the laboratory mouse, little is known about clonal selection and population dynamics of the haematopoietic stem cell pool during murine ageing. We isolated stem cells and progenitors from young and old mice, identifying 221,890 somatic mutations genome-wide in 1,845 single-cell-derived colonies. Mouse stem cells and progenitors accrue approximately 45 somatic mutations per year, a rate only approximately threefold greater than human progenitors despite the vastly different organismal sizes and lifespans. Phylogenetic patterns show that stem and multipotent progenitor cell pools are established during embryogenesis, after which they independently self-renew in parallel o

SUBMITTER: Kapadia CD 

PROVIDER: S-EPMC12074984 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature