Six pairs of enantiomeric prenylated flavonoids with cytotoxic activities from Epimedium sagittatum Maxim.

ABSTRACT: In this work, six pairs of undescribed enantiomeric prenylated flavonoids, ( ±)-epimesatines J-O (1a/1b-6a/6b), were isolated from the aerial parts of Epimedium sagittatum Maxim. Their structures and absolute configurations were determined based on spectroscopic data, quantum chemical calculations of electronic circular dichroism (ECD) and ¹³C NMR, as well as ECD experiments induced by Mo₂(OAc)₄ and Rh₂(OCOCF₃)₄. The cytotoxicity assay revealed that compounds 1a/1b, 2a/2b, and 4a/4b-6a/6b demonstrated significant inhibitory effects on the viability of human breast cancer cells MCF-7 while exhibiting no obvious toxicity towards human breast epithelial cells MCF-10A. Additionally, these compounds were found to decrease the exp

SUBMITTER: Xie SS 

PROVIDER: S-EPMC12075077 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature