Transcriptome reveals the roles and potential mechanisms of CeRNA in the regulation of salivary gland development in the tick <i>Rhipicephalus haemaphysaloides</i>.

ABSTRACT:

Introduction

The salivary glands of female ticks rapidly degenerate after feeding. The mechanism involves programmed cell death mediated by an ecdysteroid receptor. A competing endogenous RNA (ceRNA) network has been established using miRNA and the competitive binding of three types of RNA (lncRNA, circRNA, and mRNA), that were demonstrated to be involved in the regulation of biological processes. However, the comprehensive expression profile and competing endogenous RNA (ceRNA) regulatory network between mRNAs and ncRNAs involved in salivary gland development remain unclear.

Methods

In the current study, we employed whole-transcriptome sequencing (RNA sequencing) at various stages of feeding to identify differentially expressed lncRNAs, circRNAs, miRNAs, and mRNAs. The ceRN

SUBMITTER: Hu S 

PROVIDER: S-EPMC12075121 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature