A decade of genomic and phenotypic adaptation of carbapenem-resistant <i>Acinetobacter baumannii</i>.

ABSTRACT:

Introduction

Acinetobacter baumannii exhibits high genomic plasticity, enabling it to acquire virulence factors and antibiotic resistance (AR). Understanding its evolutionary adaptations is crucial for developing effective therapeutic strategies.

Methods

Thirty clinical isolates collected from two distinct time periods, defined as older (2010-2013), and recent (2022-2023),- were compared phenotypically (antibiotic resistance, growth, biofilm formation, desiccation tolerance, invasiveness) and genotypically (whole-genome sequencing).

Results

All isolates displayed an extensively drug-resistant phenotype. Overall, respiratory isolates harbored a higher content of antibiotic-resistant genes (ARGs), with older isolates showing 12.5% increases in the average number

SUBMITTER: Tagueha AD 

PROVIDER: S-EPMC12075148 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature