Quantitation of regional distribution of antibodies in rat brain following systemic and intra-CNS administration.

ABSTRACT: Antibody therapy has demonstrated great potential for treating central nervous system (CNS) disorders. Since therapeutic efficacy relies on sufficient exposure in specific brain regions, quantitative understanding of antibody distribution within the brain is crucial. Additionally, insights into antibody brain distribution help elucidate how pathological antibodies accumulate during encephalitis. Accordingly, this study investigated the regional distribution of a non-target-binding antibody (trastuzumab) and a brain-target-binding antibody (anti-NMDAR1) following systemic and intra-CNS administration in rats. After systemic administration, both antibodies showed similar distribution across brain regions, with the olfactory bulb exhibiting significantly higher concentrations. Other regions h

SUBMITTER: Wu S 

PROVIDER: S-EPMC12075156 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature