Assessment of causality association between serum adiponectin levels and the risk of Alzheimer's disease and Parkinson's disease: a Mendelian randomization study.

ABSTRACT:

Background

Until recently, the association between circulating adiponectin (ADPN) levels and the risk of Alzheimer's disease (AD) and Parkinson's disease (PD) remained unclear.

Methods

We utilized public data from the IEU GWAS database to conduct a two-sample bidirectional Mendelian randomization (MR) analysis and multiple sensitivity analyses. The MR analysis was performed using the aggregated data, with the genetic risk score (GRS) serving as an instrumental variable.

Results

The MR analyses revealed no significant causal association between genetically determined ADPN levels and the risk of AD (OR_IVW = 0.852, 95% confidence interval [CI]: 0.586-1.117, p = 0.235) or PD (OR_IVW = 0.830, 95% CI: 0.780-1.156, p = 0.606). Conversely, n

SUBMITTER: Lin J 

PROVIDER: S-EPMC12075267 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature