Identification and experimental validation of biomarkers associated with mitochondrial and programmed cell death in major depressive disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) is associated with mitochondrial dysfunction and programmed cell death (PCD), though the underlying mechanisms remain unclear. This study aimed to investigate the molecular pathways involved in MDD using a transcriptomic analysis approach.

Methods

Transcriptomic data related to MDD were obtained from public databases. Differentially expressed genes (DEGs), PCD-related genes (PCDs), and mitochondrial-related genes (MitoGs) were analyzed to identify key gene sets: PCD-DEGs and MitoG-DEGs. Correlation analysis (|correlation coefficient| > 0.9, p < 0.05) was performed to select candidate genes. Protein-protein interaction (PPI) network analysis and intersection of four algorithms were used to identify key candidate genes. Machine learni

SUBMITTER: Xiong S 

PROVIDER: S-EPMC12075303 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature