RBM15-mediated metabolic reprogramming boosts immune response in colorectal cancer.

ABSTRACT:

Introduction

Immune checkpoint blockade (ICB) therapy has shown promise in treating advanced colorectal cancer, particularly in patients with microsatellite instability-high (MSI-H) tumors. However, only a subset of these patients responds favorably, highlighting the need for strategies to improve immunotherapy efficacy.

Methods

To identify potential regulators of immunotherapy response, we conducted a comprehensive analysis of colorectal cancer datasets from The Cancer Genome Atlas (TCGA). We performed multi-omics analyses and functional assays in both human and murine colorectal cancer cell lines. Additionally, we evaluated tumor growth and immune cell infiltration using syngeneic mouse models.

Results

Our analysis revealed that RNA binding motif protein 15 (RBM15)

SUBMITTER: Wang C 

PROVIDER: S-EPMC12075365 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature