³¹P-MRS saturation transfer for assessing human hepatic ATP synthesis at clinical field strength.

ABSTRACT:

Background

³¹P-magnetic resonance spectroscopy (MRS) saturation transfer (ST) allows for noninvasive investigation of liver energy metabolism by assessing flux rates of adenosine triphosphate (ATP) synthesis. However, this technique has rarely been applied at clinical field strengths because of long examination times and contamination from muscle tissue. Our aim was to establish a new method to robustly assess ATP synthesis using a clinical scanner.

Methods

A prospective single-center study was performed (January 2023-August 2024) within the German Diabetes Study. We established a suitable ³¹P-MRS ST protocol, tested it in vitro and in vivo and assessed its reproducibility. We assessed the hepatic apparent spin-lattice relaxation time of inorganic phosp

SUBMITTER: Jonuscheit M 

PROVIDER: S-EPMC12075714 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature