Emergence of transferable tigecycline and eravacycline resistance gene tet(X4) in Escherichia coli isolates from Iran.

ABSTRACT: Tigecycline (TGC) and eravacycline (ERV) are critical last-resort antibiotics used to treat complicated infections caused by extensively drug-resistant Gram-negative bacteria particularly carbapenem- and colistin-resistant Enterobacterales. The recent emergence of plasmid-mediated TGC resistance gene tet(X) in Enterobacterales of both animal and human origins represents a significant public health threat. In this study, we characterized tet(X4)-bearing Escherichia coli isolates recovered from cattle fecal samples in Iran. A total of 395 fecal samples obtained from calves were screened for tigecycline-resistant (TGC-R) E. coli by inoculating in to selective culture media containing tigecycline. The presence of tet(X) gene among the recovered TGC-R enteric bacteria was assessed using PCR. Ge

SUBMITTER: Haeili M 

PROVIDER: S-EPMC12075785 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature