Multicomponent catalyst-free regioselective synthesis and binding studies of 3-aroyl-2-methylimidazo[1,2-<i>a</i>]pyrimidines with BSA using biophysical and computational techniques.

ABSTRACT: A facile and environmentally benign protocol for regioselective synthesis of diversely substituted imidazo[1,2-a]pyrimidines 5a-h has been described via multicomponent reaction of unsymmetrical β-diketones 1, N-bromosuccinimide 2 and 2-aminopyrimidine 4 in DCM. The reaction proceeds through in situ formation of α-bromo-β-diketones 3 and their ensuing condensation with 2-aminopyrimidine without the need of any organic or inorganic catalyst. The structure of the regioisomeric product was characterized by ¹H, ¹³C NMR, heteronuclear 2D NMR and HRMS studies. The present protocol offers several advantages such as avoidance of metal-based and toxic catalysts, broad substrate scope with respect to substitutions on β-diketones, operational simplicit

SUBMITTER: Aggarwal R 

PROVIDER: S-EPMC12076138 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature