Subclinical Atherosclerosis and Cardiovascular Events Among Patients With Colorectal Cancer.

ABSTRACT:

Background

Prior studies have documented that patients with colorectal cancer (CRC) are at an increased risk of cardiovascular disease (CVD).

Objectives

To examine coronary artery calcium (CAC) as a marker of subclinical atherosclerosis and its association with major adverse cardiovascular events (MACE) in patients with CRC across the cancer treatment trajectory.

Methods

Adults with newly diagnosed CRC were enrolled in the prospective ColoCare study from 2017 to 2024. CAC was measured from routine diagnostic computed tomography (CT) and positron emission tomography-CT scans at CRC diagnosis until 5 years post-diagnosis. Atherosclerosis was defined as the presence of CAC. We used multivariable-adjusted Fine and Gray models to assess the association between CAC and MACE

SUBMITTER: Levy JA 

PROVIDER: S-EPMC12076194 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature