Celebrating 40 years of the University of Kentucky Alzheimer's Disease Research Center.

ABSTRACT: Four decades of the National Institute on Aging's sponsored research into Alzheimer's disease (AD) have resulted in symptomatic and mechanistic therapies, lifestyle interventions, increased understanding of genetic factors and protein misfolding, and descriptions of non-AD neuropathological entities that mimic AD clinical symptoms. This is an overview of contributions from one of the original ten Alzheimer Disease Research Centers (ADRCs), the University of Kentucky ADRC. We celebrate 40 years of helping the field to define early pathogenetic mechanisms underlying transitions from normal cognitive aging to impairment in our elderly community-based cohort, increased appreciation of the heterogeneity and multiple pathologies that characterize late-life dementia, strategies for therapeutic in

SUBMITTER: Schmitt FA 

PROVIDER: S-EPMC12076195 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature