Design, synthesis, herbicidal activity, and the molecular docking study of novel phenylpyrazole derivatives with strobilurin moieties.

ABSTRACT: Phenylpyrazole derivatives were innovatively designed and synthesized to fabricate novel herbicides containing strobilurin moieties. These resulting compounds were analyzed by nuclear magnetic resonance spectroscopy (NMR) and high-resolution mass spectrometry (HRMS), exhibiting high herbicidal properties against Amaranthus retroflexus. The target compounds were synthesized through cyclization, chlorination, Vilsmeier-Hack reaction, Suzuki coupling reaction, and esterification reactions. The experimental conditions were mild, and the starting materials were easy to obtain, with a separation yield of approximately 80%. Moreover, herbicidal activity of the title compounds was studied via a pot culture experiment. Compounds 7a, 7b, 7e-7g, 7i, and 7l demonstrated good inhibition on A<

SUBMITTER: Zhang W 

PROVIDER: S-EPMC12076197 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature