Dissecting the genetic determinants and biological associations between body mass index and female reproductive disorders based on genome-wide association study.

ABSTRACT:

Background

While the phenotypic link between body mass index (BMI) and some female reproductive disorders is well established, the genetic architecture and causal relationships have not been systematically studied. We aimed to create an atlas of the shared genetic associations of BMI and 16 female reproductive disorders and to identify their common risk loci, biological pathways, and potential mechanisms.

Methods

We assessed the genetic correlations between BMI and 16 reproductive disorders using summary data from large-scale genome-wide association studies. Cross-trait pleiotropic analysis identified shared loci and genes, while functional annotation and tissue-specific analysis revealed relevant biological pathways and tissues. Multi-trait colocalization analysis examined

SUBMITTER: Shao H 

PROVIDER: S-EPMC12076840 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature