Design, synthesis, biological evaluation, and computational insights of 2-(Aryl)benzo[d]imidazo[2,1-b]thiazole-7-sulfonamide derivatives as potent antitubercular and antibacterial agents.

ABSTRACT: A series of 2-(aryl)benzo[d]imidazo[2,1-b]thiazole-7-sulfonamide derivatives were synthesized and evaluated for their antitubercular and antibacterial activities, molecular docking, and DFT studies. The compounds were synthesized through a multi-step reactions, with yields varying based on the electronic and steric effects of the substituents. Among the derivatives, 5b, 5d, and 5h exhibited potent antitubercular activity against Mycobacterium tuberculosis (H37Rv strain) with minimum inhibitory concentrations (MICs) of 1.6 µg/mL, comparable to some standard drugs like isoniazid. Antibacterial testing revealed that 2-(2,4-dichlorophenyl)benzo[d]imidazo[2,1-b]thiazole-7-sulfonamide displayed significant activity against Gram-positive bacteria, with MICs as low as 6.25 µg/mL for Staphylococcus

SUBMITTER: Deshmukh HS 

PROVIDER: S-EPMC12076927 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature