White matter and cortical gray matter microstructural alterations in migraine: a NODDI and DTI analysis.

ABSTRACT:

Background

The pathophysiological mechanism of migraine remains elusive, thereby impeding the effective treatment of the disease. Current neuroimaging research focuses on changes in brain functional connectivity, functional networks, and macrostructural alterations, which reflect abnormal neuronal function during the disease process. The plasticity changes in neuronal structures and neurotransmitter system dysregulations potentially play a crucial role in migraine onset and chronicity of migraine. This study utilizes multimodal neuroimaging techniques to investigate the microstructural and neurotransmitter alterations in migraine and provides new insights into its pathological mechanisms and therapeutic method.

Methods

Microstructural alterations in both white matter (WM) an

SUBMITTER: Li Z 

PROVIDER: S-EPMC12076971 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature