Effects of melatonin in polycystic ovary syndrome: is there Hippo pathway crosstalk?

ABSTRACT:

Objective

Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder among reproductive women, characterized by hyperandrogenism, oligo-ovulation and polycystic ovarian morphology. Incorporating complementary medicine alongside traditional lifestyle therapies for PCOS may offer additional benefits for affected women. Melatonin (MT), a hormone secreted by the pineal gland, has emerged as a potential treatment for regulating ovarian function in PCOS. However, the specific effects and underlying mechanisms of MT on PCOS need to be elucidated.

Methods

This review consolidates evidence from randomized controlled trials, original research articles, systematic reviews, and meta-analyses regarding MT supplementation in PCOS, with a particular focus on its interaction with th

SUBMITTER: Wang L 

PROVIDER: S-EPMC12076993 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature