Neutrophil extracellular traps-related genes contribute to sepsis-associated acute kidney injury.

ABSTRACT:

Background

Neutrophil extracellular traps (NETs) and oxidative stress (OS) may be involved in sepsis-associated acute kidney injury (SA-AKI). The aim of this study was to identify potential regulators which modulate NETs and OS in SA-AKI, and to find potential therapeutic agents.

Methods and materials

SA-AKI-related datasets GSE255281 and GSE225192 were downloaded from Gene Expression Omnibus. Molecular subtypes associated with NETs were identified by unsupervised clustering. The OS-related genes were obtained by weighted gene co-expression network analysis. Differentially expressed genes were screened by "limma" package in R. Least absolute shrinkage and selection operator algorithm was applied to identify the hub genes. Additionally, the biological functions of the hub gen

SUBMITTER: Shaoqun T 

PROVIDER: S-EPMC12077042 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature