Non-linear associations between renal perfusion pressure indexes and AKI incidence and recovery rate.

ABSTRACT:

Background

Renal perfusion pressure plays a crucial role in the pathophysiology of acute kidney injury (AKI). While multiple methods are available for calculating renal perfusion pressure, the optimal calculation approach and its true correlation with AKI remain uncertain. This study aims to investigate the nonlinear relationship between various perfusion pressure indices and AKI, clarifying the connection between perfusion pressure, AKI onset, and recovery.

Methods

Three renal perfusion pressure indices were calculated: MAP-CVP, MAP-Plateau pressure, and MAP-CVP-Plateau pressure. Restricted cubic spline (RCS) analysis was used to examine the association between these perfusion indices and AKI incidence. The relationship between MAP-CVP-Plateau pressure and both AKI occurren

SUBMITTER: Ding X 

PROVIDER: S-EPMC12077046 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature