Longitudinal host-microbiome dynamics of metatranscription identify hallmarks of progression in periodontitis.

ABSTRACT:

Background

In periodontitis, the interplay between the host and microbiome generates a self-perpetuating cycle of inflammation of tooth-supporting tissues, potentially leading to tooth loss. Despite increasing knowledge of the phylogenetic compositional changes of the periodontal microbiome, the current understanding of in situ activities of the oral microbiome and the interactions among community members and with the host is still limited. Prior studies on the subgingival plaque metatranscriptome have been cross-sectional, allowing for only a snapshot of a highly variable microbiome, and do not include the transcriptome profiles from the host, a critical element in the progression of the disease.

Results

To identify the host-microbiome interactions in the subgingival milieu

SUBMITTER: Duran-Pinedo A 

PROVIDER: S-EPMC12077055 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature