Rapid prediction of carbapenemases in <i>Pseudomonas aeruginosa</i> by imipenem/relebactam and MALDI-TOF MS.

ABSTRACT: Pseudomonas aeruginosa is a major nosocomial pathogen commonly involved in multidrug-resistant (MDR) infections that are very difficult to treat. Imipenem/relebactam is a new carbapenem/β-lactamase inhibitor combination with robust activity against P. aeruginosa. However, resistance is increasingly reported, and rapid detection is, therefore, crucial so that appropriate treatments can be prescribed. We have developed a rapid MALDI TOF-MS-based method that can accurately predict the presence of carbapenemases in P. aeruginosa using imipenem/relebactam. The method was developed using a retrospective and a prospective collection of 419 P. aeruginosa isolates (including recombinant isolates and WGS-characterized clinical strains) encompassing the most importa

SUBMITTER: Candela A 

PROVIDER: S-EPMC12077086 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature