Population structure of <i>Helicobacter pylori</i> and antibiotic resistance-associated variants in a high-risk area of gastric cancer.

ABSTRACT: The increasing antibiotic resistance of Helicobacter pylori has had a serious impact on gastric cancer prevention. Our study aimed to profile the genomic characteristics and explore variants associated with resistance in H. pylori strains from a high-risk area of gastric cancer in China. We isolated 153 strains from a community-based cohort and assessed their susceptibility to six antibiotics by MIC Test Strip and genomic characteristics by whole-genome sequencing. Phylogenetic analysis identified the strains as an independent cluster within H. pylori East Asian population (hpEastAsia). HefA, an efflux pump gene, showed the highest differentiation in the Linqu strains compared with the other Chinese strains. Bacterial genome-wide association study (GWAS) identif

SUBMITTER: Jin Q-Y 

PROVIDER: S-EPMC12077087 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature