Evolution of PqsE as a <i>Pseudomonas aeruginosa</i>-specific regulator of LuxR-type receptors: insights from <i>Pseudomonas</i> and <i>Burkholderia</i>.

ABSTRACT: Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that poses a significant public health threat, particularly in healthcare settings. A key determinant of P. aeruginosa virulence is the regulated synthesis and release of extracellular products, which is controlled by a cell density-dependent signaling system known as quorum sensing (QS). P. aeruginosa uses a complex QS network, including two systems that rely on diffusible N-acylhomoserine lactone (AHL) signal molecules. The LuxR-type receptor RhlR is unique in that it requires not only its cognate AHL but also the accessory protein PqsE to maximally bind to promoter DNA and initiate transcription. Our group previously demonstrated that PqsE physically interacts with RhlR, enhancing its affinity for targ

SUBMITTER: Mallery CP 

PROVIDER: S-EPMC12077149 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature