Characterization of proteins present in the biofilm matrix and outer membrane vesicles of <i>Histophilus somni</i> during iron-sufficient and iron-restricted growth: identification of potential protective antigens through <i>in silico</i> analyses.

ABSTRACT: There is limited efficacy in vaccines currently available to prevent some animal diseases of bacterial origin, such as bovine respiratory disease caused by Histophilus somni. Protective efficacy can potentially be improved if bacterial antigens that are expressed in the host are included in vaccines. During H. somni infection in the bovine host, biofilms become established, and the availability of essential iron is restricted. To investigate further, the protein composition of spontaneously released outer membrane vesicles (OMVs) during iron-sufficient and iron-restricted growth and the proteins expressed in the biofilm matrix were analyzed and compared. Proteomic analysis revealed a dramatic physiological change in H. somni as it transitioned from the planktonic form

SUBMITTER: Lee Y-J 

PROVIDER: S-EPMC12077179 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature