Polyfunctional CD8⁺CD226⁺RUNX2^hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia.

ABSTRACT: CD8⁺ T cells, a subset of T cells identified by the surface glycoprotein CD8, particularly those expressing the co-stimulatory molecule CD226, play a crucial role in the immune response to malignancies. However, their role in chronic lymphocytic leukemia (CLL), an immunosuppressive disease, has not yet been explored. We studied 64 CLL patients and 25 age- and sex-matched healthy controls (HCs). We analyzed the proportion of CD226-expressing cells among different CD8⁺ T cell subsets (including naïve, central memory, effector memory, and effectors) in CLL patients, stratified by Rai stage and immunoglobulin heavy-chain variable region gene (IgHV) mutation status. Additionally, we compared the effector functions of CD8⁺CD226⁺ cells and their CD226

SUBMITTER: Rezaeifar M 

PROVIDER: S-EPMC12077284 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature