Disparity landscapes of viral-induced structural variations in HCC: Mechanistic characterization and functional implications.

ABSTRACT:

Background and aims

HCC is the most common type of primary liver cancer and is a common malignancy worldwide. About half of all new liver cancers worldwide each year occur in China, including Hong Kong, due to a high prevalence of HBV infection. HBV DNA integrates into the human genome, disrupting the endogenous tumor suppressors/regulatory genes or enhancing the activity of proto-oncogenes. It would be useful to examine the different NGS-based databases to provide a more unbiased and comprehensive survey of HBV integration.

Approach and results

We aimed to take advantage of publicly available data sets of different regional cohorts to determine the disparity landscapes of integration events among sample cohorts, tissue types, chromosomal positions, individual host, and vira

SUBMITTER: Lyu X 

PROVIDER: S-EPMC12077337 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature