Tamdy virus pathogenesis in immunocompetent and immunocompromised mouse models.

ABSTRACT: Tamdy virus (TAMV) is one of the zoonotic tick-borne bunyaviruses that have emerged as global public health threats in recent decades. To date, however, TAMV pathogenesis remains poorly understood. In the present study, we have established different mouse infection models to enable investigation of TAMV pathogenesis. Adult BALB/c mice did not exhibit obvious clinical symptoms or signs post-TAMV infection. In contrast, adult type I interferon receptor knockout (IFNAR^-/-) A129 mice were found to be susceptible to high-doses of TAMV (6 × 10² and 6 × 10⁴ FFU) and all developed severe clinical symptoms and signs, including weight loss and immobility, and reached the euthanasia criteria at 4/5-day post-infection (dpi). Viral RNA was detected in peripheral blood a

SUBMITTER: Cui M 

PROVIDER: S-EPMC12077439 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature