Genomic epidemiology and antifungal resistance of emerging <i>Trichophyton indotineae</i> in China.

ABSTRACT: The emergence and spread of antifungal-resistant Trichophyton indotineae pose an increasing public health concern worldwide. Multidrug-resistant T. indotineae infections have been reported in China in the past few years. To understand the genetic relationship and the origin of these Chinese isolates, as well as their relationship to the global collections, we sequenced the whole genomes of 31 isolates using the Illumina platforms. Genomic epidemiology was performed on a dataset of 181 T. indotineae isolates from China and 8 other countries, representing the largest genome-wide analysis. Single nucleotide polymorphism analysis revealed that T. indotineae can be divided into four distinct phylogenetic groups (I, II, III, IV), with regional clonal transmission clus

SUBMITTER: Xie W 

PROVIDER: S-EPMC12077451 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature