Relationships among biological sex, body composition, and bone mineral density in young persons with and without diabetes.

ABSTRACT:

Objectives

Bone mineral density (BMD) is influenced by factors including age, sex, body composition, and diabetes. However, data regarding these relationships in young individuals is limited. The objective of this study was to address this gap in the literature.

Methods

We conducted a post-hoc analysis of participants from six cross-sectional cohort studies, encompassing individuals with type 1 diabetes (T1D) and type 2 diabetes (T2D), as well as controls of healthy weight (HWC) and with obesity (OC). Whole-body dual-energy X-ray absorptiometry (DXA) was employed to measure BMD and body composition. Multiple linear regression models assessed sexual dimorphism in BMD, adjusting for age and exploring effect modification by group and sex.

Results

A total of 325 participa

SUBMITTER: Platnick C 

PROVIDER: S-EPMC12077546 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature