Cellular effects of splenectomy on liver regeneration after 70% resection.

ABSTRACT:

Introduction

Mammalian liver regeneration is a complex process, the regulation of which involves many mechanisms. The immune system has a pronounced influence on the course of reparative processes in mammals. The hepatic portal vein system provides a direct anatomical connection between the liver and the spleen - the largest lymphoid organ in mammals. Accordingly, the spleen may have a direct effect on liver regeneration as a source of biologically active substances and migrating leukocytes. Specific mechanisms of such influence remain understudied. This study aimed to assess the effect of splenectomy on liver regeneration after 70% resection in mouse model.

Methods

Murine model of liver regeneration after 70% resection was reproduced in C57BL/6 male mice, some of them splen

SUBMITTER: Elchaninov A 

PROVIDER: S-EPMC12078306 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature