Unveiling the heritability of selected unexplored pharmacogenetic markers in the Saudi population.

ABSTRACT:

Background

Pharmacogenomic (PGx) variants can significantly impact drug response, but limited data exists on their prevalence in Middle Eastern populations. This study aimed to investigate the inheritance of certain markers in candidate pharmacogenes among healthy Saudis.

Methods

DNA samples from 95 unrelated healthy Saudi participants were genotyped using the Affymetrix Axiom Precision Medicine Diversity Array. Thirty-eight variants in 15 pharmacogenes were analyzed based on their clinical relevance and lack of previous reporting in Saudi populations.

Results

Twenty-six of the 37 tested markers were undetected in the cohort. The selected variants in six genes [DPYD (rs1801268), CACNA1S (rs772226819), EGFR (rs121434568), RYR1 (rs193922816),

SUBMITTER: Alshabeeb MA 

PROVIDER: S-EPMC12078325 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature