The Abnormal ERα-miRNA Cross-Talk in AD-Affected Human Hippocampus: A Bioinformatics Perspective.

ABSTRACT: Estrogen's impact on Alzheimer's disease (AD) is multifaceted, with its receptors potentially influencing AD pathology in both beneficial and detrimental ways. This study aims to dissect the intricate cross-talk between estrogen receptor alpha (ERα) and microRNAs (miRNAs) in AD-affected human hippocampus. Through a comprehensive literature review in the PubMed database, coupled with a GeneCards database search, we obtained AD-related key miRNAs and genes in the hippocampus. Using bioinformatics tools, we predicted target genes and miRNAs of ERα, and the targets of the identified miRNAs. The integration of these elements resulted in the construction of an ERα-related FFL network, which includes 13 miRNAs and 56 core genes. Gene ontology (GO) and pathway enrichment analyses were conducted, r

SUBMITTER: Liu FF 

PROVIDER: S-EPMC12078360 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature