Identification of causal plasma metabolite biomarkers for ischemic stroke using Mendelian randomization and mediation analysis.

ABSTRACT: The Global Burden of Disease Study 2021 reports that stroke remains a leading cause of death, with ischemic stroke (IS) presenting significant challenges in screening, prevention, and treatment. We explored the causal effects of 1,400 plasma metabolites on IS outcomes using a two-sample Mendelian randomization (MR) framework. We assessed causal relationships between IS and 11 common clinical risk factors and further examined these relationships for metabolites. Mediation analysis identified mechanisms for metabolites affecting both IS and its risk factors. Finally, a phenome-wide association study (PheWAS) MR analysis evaluated the side effects and additional indications of IS-associated metabolites across 3,948 phenotypes from the UKBB GWAS. Nineteen metabolites showed a causal relationsh

SUBMITTER: Lyu J 

PROVIDER: S-EPMC12078489 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature