Dissecting immune-mediated pathways in rheumatoid arthritis: A multivariate mediation analysis of antibodies and circulating proteins.

ABSTRACT: Rheumatoid arthritis (RA) is a chronic inflammatory disorder with complex etiologies involving immune responses and circulating proteins. This study investigates the causal relationships between antibody immune responses, plasma circulating proteins, and the development of RA using Mendelian Randomization (MR) analysis; A two-sample and multivariate MR analysis was conducted to explore the mediating causal relationship between 46 antibody immune responses and RA through 4,907 plasma circulating proteins. Genetic variations were utilized as instrumental variables (IVs) to infer causality, ensuring that they met the assumptions of relevance, independence, and exclusion restriction. Data were sourced from the FinnGen R10 dataset, UK Biobank, and the SomaScan platform, providing a robust found

SUBMITTER: Niu J 

PROVIDER: S-EPMC12078495 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature