T antigens of simian virus 40: molecular chaperones for viral replication and tumorigenesis.

ABSTRACT: Simian virus 40 (SV40) is a small DNA tumor virus that has been extensively characterized due to its relatively simple genetic organization and the ease with which its genome is manipulated. The large and small tumor antigens (T antigens) are the major regulatory proteins encoded by SV40. Large T antigen is responsible for both viral and cellular transcriptional regulation, virion assembly, viral DNA replication, and alteration of the cell cycle. Deciphering how a single protein can perform such numerous and diverse functions has remained elusive. Recently it was established that the SV40 T antigens, including large T antigen, are molecular chaperones, each with a functioning DnaJ domain. The molecular chaperones were originally identified as bacterial genes essential for bacteriophage gro

SUBMITTER: Sullivan CS 

PROVIDER: S-EPMC120785 | biostudies-literature | 2002 Jun

REPOSITORIES: biostudies-literature