Comparison of inter- and intraobserver agreement between [¹⁸F]AlF-NOTA-octreotide and [⁶⁸Ga]Ga-DOTA-SSA PET/CT.

ABSTRACT:

Purpose

This study compares inter- and intraobserver agreement between [¹⁸F]AlF-NOTA-octreotide ([¹⁸F]AlF-OC) and [⁶⁸Ga]Ga-DOTA-somatostatin analogues (SSAs) in PET/CT imaging for neuroendocrine neoplasm (NEN) patients.

Materials and methods

This is a secondary endpoint analysis from our multicenter trial (clin trial.gov identifier: NCT04552847) including 75 NEN patients who received both [⁶⁸Ga]Ga-DOTATATE (n = 56) or [⁶⁸Ga]Ga-DOTA-NOC (n = 19) and [¹⁸F]AlF-OC PET imaging. Five readers assessed lesion detection and characterization across multiple organs, scoring lesions by number and conspicuity using a 5-point Likert scale. Agreement was measured using Gwet's agreement coefficient.

Results

Results dem

SUBMITTER: Leupe H 

PROVIDER: S-EPMC12078903 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature