A Causal Association Study Between Chronic Kidney Disease and Oral Health: A Mendelian Randomization Study.

ABSTRACT:

Background and aims

Previous studies have shown that chronic kidney disease (CKD) can lead to changes in oral health, but the conclusions remain controversial. Thus, we conducted a Mendelian randomization (MR) study from the perspective of genetic analysis to assess the causal association between CKD and oral health conditions, including dental caries, pulp diseases, periapical tissues, and diseases of the gum and periodontal tissues.

Methods

We performed inverse variance weighted (IVW) random effects MR analyses and several sensitivity MR analyses using summary statistics from genome-wide association studies (GWAS). The data were derived from the European population in 2021, which included 3902 cases of CKD, 4170 cases of dental caries, 5354 cases of diseases of the pulp an

SUBMITTER: Zhang G 

PROVIDER: S-EPMC12079086 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature